منابع مشابه
Estrogens, BRCA1, and breast cancer.
Findings obtained in in vitro assays and animal studies indicate that estrogens might influence the activity of the tumor suppressor gene BRCA1, and BRCA1 in turn may suppress the activity of the estrogen receptor. This review will discuss the possibility that interactions between estrogens and BRCA1 partly explain why elevated circulating estrogen levels appear to increase breast cancer risk a...
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Breast cancer is the most common cancer in women. Several risk factors such as age, family history of breast cancer, marital status, early menarche and late menopause are related to breast cancer. Obesity is also a main health problem associated with breast cancer incidence and subsequent mortality. Association between obesity and expansion of breast cancer may be due to excessive sex steroid h...
متن کاملSimilarities of prostate and breast cancer: Evolution, diet, and estrogens.
Environment determines the risk of both prostate and breast cancer, and this risk can vary >10-fold. In contrast, no risk exists for human seminal vesicle cancer demonstrating tissue specificity. There is also species specificity, because there is no risk for prostate cancer in any other aging mammal except the dog. A study of evolution indicates that the prostate and breast appeared at the sam...
متن کاملEstrogens and organochlorine xenoestrogens and breast cancer risk.
Breast cancer is responsible for considerable morbidity and the majority of female deaths in industrialized countries. In the etiology of breast cancer many endogenous and exogenous risk factors have been discussed. It is estimated that about 40% of all cancers in women are hormonally mediated. Both estrogens and androgens play critical roles in the development of breast cancer, which has been ...
متن کاملAlcohol Abuse and Oral Cancer
Background: Various medical, psychiatric and social problems affecting alcohol abuser tend to overshadow their oral health. From an epidemiologic viewpoint, chronic consumption of alcoholic beverages is associated with an increased risk for the upper gastrointestinal tract cancer, and tobacco and alcohol are regarded as the major risk factors for oral cancer. The objective of this presentation ...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1997
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.82.7.4098